Adapted from BMJ 7-14 Feb 2026
A systemic review and network analysis of 76 randomised controlled trials has found that relapses of anti-depressant medication can be completely avoided by bringing down the dose slowly, and by providing psychological support.
Relapse after stopping these drugs is common and many people can be on them for much longer than originally anticipated as a result.
Relapses are a lot higher if the drugs are stopped abruptly or tapered rapidly.
Meanwhile other researchers have been looking into genetic markers for psychiatric illness. Unlike disorders like Huntington’s disease, which is a single gene disorder, most psychiatric illness is due to the influence of multiple genes.
Schizophrenia and Bipolar disorder overlap extensively genetically.
Depression, anxiety, and post traumatic stress disorder also show this overlap with each other.
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