One in 20 type two diabetics get into remission

Photo by Charlotte May on Pexels.com

Adapted from BMJ Dec 4 2021

A Scottish study showed that one in 20 people diagnosed with type two diabetes gained remission long term. This was defined as having a HbA1c of below 48 mmol/mol.

In comparison with those who did not gain remission, they tended to be older, to have a lower HbA1c at diagnosis, not to have taken glucose lowering medications, and to have lost weight since diagnosis. They were also more likely to have had bariatric surgery.

A review of weight loss diets in diabetics reported in Diabetolgia, reported gloomy results for all of the diets that they reviewed. Meaningful weight loss did not occur often.

These included low carbohydrate diets, high protein, Mediterranean and vegetarian. The best results were for low calorie liquid shakes when these replaced normal food. But even then the weight loss was only a few kilograms.

Most people with type two diabetes need to lose weight to improve their cardiovascular risk, especially if they don’t want to rely on lifelong medication.

Dr David Ludwig: Childhood obesity the the crossroads of science and social justice

Photo by Loren Castillo on Pexels.com

Adapted from paper by Dr David S Ludwig and Dr Jens J Holst published in JAMA May 1 2023

Treatment that focuses on the root cause of a disease has guided research and clinical practice for centuries. The American Academy of Pediatrics (AAP) published a clinical practice guideline for the evaluation and treatment of children with obesity earlier this year. This guideline emphasises the use of weight loss drugs and bariatic surgery. Diet received little attention apart from advising the USDA’s MyPlate recommendations and the limitation of sugar sweetened beverages.

The researchers are of course constrained by available evidence and the results on weight loss for drugs and surgery do seem superior to the changes achieved by diet. Yet, the physiological changes that occur on a carbohydrate restricted diet have many similarities to what occurs in the body with drugs such as GLP-1 receptor antagonists.

GLP-1 RAs improve beta cell sensitivity to glucose so that the same amount of insulin will be released at a lower glucose concentration. It also slows the rate that the stomach empties after eating food. Thus people feel fuller up after eating for longer, and the lower blood sugars released from the stomach over time result in lowering the total amount of insulin from the pancreas. The lower the rate that the stomach empties, the more weight is lost.

Slower digesting carbohydrate, for instance, must travel farther down the gut before being fully absorbed. This causes lower post meal blood sugars and insulin secretion. Protein and fat also digest more slowly and stimulate less insulin secretion than an equivalent amount of rapidly absorbed carbohydrate. Additional similarities between low glycaemic load diets and GLP-1 RAs include lower leptin levels, suggesting lower leptin resistance, lower ghrelin levels and higher adiponectin levels. This dietary strategy shares mechanisms with gastric bypass surgery which shifts nutrient absorption from a more proximal to a more distal location in the intestines. Of special relevance is that natural GLP-1 secretion is increased with a low glycaemic load diet, which slows gastric emptying thus improving satiety, and bariatric surgery.

Although in theory a low carb diet should be able to replicate the results of GLP-1 RAs (15% weight loss) results are usually disappointing, except where a ketogenic diet with intensive behavioural support (12% weight loss) is provided. In other words, the results can be almost replicated but the person must stick to the diet.

GLP-1 RAs cost $1,400 per adolescent per month. Treatment of all adults with obesity would cost $1 trillion and all adolescents $100 billion per year. Instead of spending this sort of money to solve the obesity crisis, it would be more worthwhile to enhance dietary quality and create environments that would encourage physical activities and outdoor play as an alternative to screen time and electronic gadgets. This would improve mental as well as physical health.

Unfortunately, once GLP-1 RAs are stopped, the weight is usually rapidly regained. Therefore we are really looking at potentially lifelong drug treatment for the obese population. We do not know the effects of prolonged drug treatment on other health factors. A low quality diet could still produce a raised lifetime risk of cardiovascular disease, cancer and other chronic conditions, independent of weight.

Perhaps low glycaemic load diets when given in conjunction with GLP-1 RAs would improve the therapeutic effect and thus allow drug use at lower dosages. This could reduce adverse effects.

To advance science and social justice we must fund research into new dietary treatments and overcome obstacles to the provision of intensive behavioural interventions. Especially for children, diet and lifestyle must remain at the forefront of obesity prevention and treatment.

Worsening obesity in children can be reversed with a ketogenic diet

Photo by Alexander Dummer on Pexels.com

Adapted from Independent Diabetes Trust Newsletter March 2023

The National Child Measurement Programme 16 March 2022

In the western world obesity rates continue to climb in children. In the UK when children start primary school at the age of 4-5 14.4% are obese and a further 13.3% are overweight. In Primary 6, at the age of 10-11 25.5% are obese and 15.4% are overweight.

My comment: from my own schooldays, there was only one overweight child in my primary class and she was on steroids and had a heart complaint that stopped her from participating in any exercise. In primary 7, there was one girl who was overweight and she had started puberty earlier than the rest of us.

In the USA in 2019 more than 30% of children were overweight or obese, similar to the UK figures. Physicians are reporting that since the Covid epidemic children are usually between 5 and 10 pounds heavier than they were at any given age, so these figures are likely to worsen even more.

Since 2006 Duke University has treated more than 15,000 children with a restricted carbohydrate diet which encourages the eating of vegetables, fatty fish, nuts and other features of the Mediterranean diet.

Meghan Pauley and colleagues from the Marshall University School of Medicine in Huntington West Virginia have cut the carbohydrate intake for children further to 30g or less a day and have been effective in short term weight loss in severely obese children and teenagers.

The ages of the subjects ranged from 5 years to 18 years. The study lasted 3-4 months. The children were otherwise told to eat as much fat and protein as desired with no limit on calories.

Two groups of analyses were done of different intakes into the programme in 2017 and 2018.

 In Group A, 310 participants began the diet, 130 (42%) returned after 3-4 months. Group B had 14 enrollees who began the diet, and 8 followed up at 3-4 months (57%).

Girls compared with boys were more likely to complete the diet. Participants less than 12 years age were almost twice as likely to complete the diet compared with those 12-18 years, however, the older group subjects who completed the diet had the same percentage of weight loss compared with those under 12 years. Group A had reductions in weight of 5.1 kg , body mass index (BMI) 2.5 kg/m2 , and percentage weight loss 6.9% .

Group B had reductions in weight 9.6 kg , BMI 4 kg/m2 , and percentage weight loss 9% . In addition, participants had significant reductions of fasting serum insulin and triglycerides.

This study demonstrated that a carbohydrate-restricted diet, utilized short term, effectively reduced weight in a large percentage of severely obese youth, and can be replicated in a busy primary care office.

No chips with mine thanks!

Photo by Glady Francis on Pexels.com

After considerable number crunching a low carb colleague has come to the very reasonable conclusion that the worst food in the world for weight gain is the fried potato in its several incarnations.

In the USA French Fries are what we in the UK call Chips. In the USA Chips are what we in the UK call Crisps.

These are ubiquitous and difficult to avoid particularly if you eat in fast food restaurants. Even if you order a sandwich you may be given a side order of chips or crisps.

Tucker explains that the vegetable and seed oils that these items are fried in play havoc with the appetite control centres of your brain. This article serves as a reminder, since we are all still at least trying to keep to our New Year’s Resolutions, why it would be better to avoid having them on your plate or hand in the first place. And just the one or two….who are you kidding?

https://yelling-stop.blogspot.com/2021/10/whats-most-fattening-food.html

Low carb diets are beneficial for weight normalisation after childbirth

Photo by Creation Hill on Pexels.com

Everyone knows how hard it is to shift body fat after having a baby. A recent study suggests that adopting a low carb diet featuring plentiful meat/poultry/fish and animal fats was more successful than having a low carb diet based mainly around plant foods.

Readers who are keen to shed their post holiday season weight gain may also find this information useful.

Low-carbohydrate diets (LCD) have been considered a popular dietary strategy for weight loss. However, the association of the low-carbohydrate dietary pattern with postpartum weight retention (PPWR) in women remains unknown.

The present study involved 426 women from a prospective mother-infant cohort study.

Overall, animal or plant LCD scores, which represent adherence to different low-carbohydrate dietary patterns, were calculated using diet intake information assessed by three consecutive 24 h dietary surveys.

PPWR was assessed by the difference of weight at 1 year postpartum minus the pre-pregnancy weight. After adjusting for potential confounding variables, women in higher quartiles of total and animal-based LCD scores had a significantly lower body weight and weight retention at 1 year postpartum (P < 0.05). The multivariable-adjusted ORs of substantial PPWR (≥5 kg), comparing the highest with the lowest quartile, were 0.47 (95% confidence interval 0.23–0.96) for the total LCD score (P = 0.021 for trend) and 0.38 (95% confidence interval 0.19–0.77) for the animal-based LCD score (P = 0.019 for trend), while this association was significantly attenuated by rice, glycemic load, fish, poultry, animal fat and animal protein (P for trend <0.05).

A high score for plant-based LCD was not significantly associated with the risk of PPWR (P > 0.05). The findings suggested that a low-carbohydrate dietary pattern, particularly with high protein and fat intake from animal-source foods, is associated with a decreased risk of weight retention at 1 year postpartum. This association was mainly due to low intake of glycemic load and high intake of fish and poultry.

https://pubs.rsc.org/en/content/articlelanding/2021/fo/d1fo00935d

Wondering if fasting is worth the pain?

Carbohydrate restriction regulates the adaptive response to fasting
S. Klein and R. R. Wolfe 
Department of Internal Medicine, University of Texas Medical Branch, Galveston.
The importance of either carbohydrate or energy restriction in initiating the metabolic response to fasting was studied in five normal volunteers.

The subjects participated in two study protocols in a randomized crossover fashion. In one study the subjects fasted for 84 h (control study), and in the other a lipid emulsion was infused daily to meet resting energy requirements during the 84-h oral fast (lipid study).

Glycerol and palmitic acid rates of appearance in plasma were determined by infusing [2H5]glycerol and [1-13C]palmitic acid, respectively, after 12 and 84 h of oral fasting.

Changes in plasma glucose, free fatty acids, ketone bodies, insulin, and epinephrine concentrations during fasting were the same in both the control and lipid studies.

Glycerol and palmitic acid rates of appearance increased by 1.63 +/- 0.42 and 1.41 +/- 0.46 mumol.kg-1.min-1, respectively, during fasting in the control study and by 1.35 +/- 0.41 and 1.43 +/- 0.44 mumol.kg-1.min-1, respectively, in the lipid study.

These results demonstrate that restriction of dietary carbohydrate, not the general absence of energy intake itself, is responsible for initiating the metabolic response to short-term fasting.

Dr Michael Eades: Omega 6 fats make you fat way beyond their caloric value

There is a hypothesis gaining ground which is that the omega 6 fats in vegetable oil disrupt metabolism and promote fat gain way beyond their simple caloric value.

Dr Michael Eades explains the epidemiology which suggests that this is the case and then the biochemistry which provides a plausible explanation.

This video is 45 minutes long and is quite technical in parts.

 

Abstract and video here:

https://denversdietdoctor.com/dr-michael-eades-a-new-hypothesis-of-obesity/

 

 

 

 

Kris Kresser: Everything you need to know about a ketogenic diet

A Complete Guide to the Keto Diet
by Chris Kresser
Published on April 2, 2019
Ketogenic diets are currently all the rage. Seemingly every health personality has an opinion on the ketogenic diet, commonly referred to as “keto.” Some tout it as a cure-all for everything from diabetes to cancer, while others express skepticism or disagree with some aspects of the diet.

The keto diet could help alleviate conditions like obesity and type 2 diabetes and even impact the progression of some types of cancer, but it isn’t for everyone.

It’s understandable that you may be wondering how to sort out the facts and interpret the latest research. Who is a good candidate for keto, and who should avoid it? How does someone successfully adhere to a ketogenic diet? In this article, I’ll answer these important questions and others so you can make an educated decision about whether keto is right for you.

What is the keto diet?
Nine conditions that respond well to keto
Who should avoid the diet
The keto time frame
Three steps to starting keto
13 tips and tricks
What to expect on keto
What Is the Keto Diet?
The ketogenic diet is a high-fat, moderate-protein, low-carb food plan. The typical macronutrient ratios are 60 to 75 percent of calories from fat, 15 to 30 percent of calories from protein, and 5 to 10 percent of calories from carbohydrates.
By strictly limiting dietary carbohydrates, the ketogenic diet encourages the body to switch from using glucose as a primary fuel source to burning body fat and using ketones for fuel. This metabolic switch has a variety of beneficial effects on the body, ranging from fat loss to improved brain function.
The keto diet could potentially address a number of health conditions, such as obesity, type 2 diabetes, and even cancer. Check out this article for more information on who should try keto—and who shouldn’t—and get tips to help you. #lowcarb #nutrition #chriskresser

A ketogenic diet differs dramatically from the carbohydrate-heavy Standard American Diet. When you eat a carbohydrate-rich meal, the ingested carbs are broken down into glucose. Glucose is then shuttled into cells by insulin, where it is used for energy production. The constant consumption of a high-carbohydrate diet causes the body to rely on glucose (sugar) for fuel, while rarely tapping into fat stores for energy. A ketogenic diet does just the opposite. It forces the body to turn to fats for fuel. A keto diet encourages the production of ketones, small water-soluble compounds, and the “burning” of fatty acids in adipose tissue (fat cells) for energy. Ketones are unique in that they are rapidly taken up by tissues and broken down to yield ATP, the primary energy currency of the human body. The process by which the body switches to using ketones for energy is referred to as “nutritional ketosis,” while the process of tapping into your body’s fat stores is termed “fat adaptation.”

Choosing the right diet can be a difficult process of trial and error. Health coaches support people in finding the best diet for their bodies, lifestyles, families—wherever they need encouragement in discovering the right path, etc. As a coach, you learn to ask the questions that help people figure out whether a diet is the right fit for them. This not only helps them make a good choice but minimizes the time they spend with diets that don’t work well for them.

Health coaches can also help people navigate their chosen diets, like the ketogenic diet. As an example, some people may need a little extra push getting their bodies to transition to using ketones. If you are finding it difficult to get into ketosis, a health coach can help you navigate that process.
How do health coaches do this? In our ADAPT Health Coach Training Program, you learn about a variety of diets—including the ketogenic diet—how they work, who they work well for, and how to support people in making diet transitions. Visit our health coach training program page to find out more.

The ADAPT Health Coach Training Program is an Approved Health and Wellness Coach Training & Education Program by the National Board for Health and Wellness Coaching (NBHWC).
Nine Conditions That Are Ideal for Keto
The ketogenic diet offers many health benefits, but it isn’t right for everyone. Read on to learn who stands to benefit the most from keto and which conditions tend to respond the best to the diet.
1. Obesity
Disturbing statistics indicate that weight problems have reached epidemic proportions in the United States, with nearly 72 percent of American adults 20 and over categorized as overweight or obese. (1) The mandate that overweight and obese individuals should merely “eat less and exercise more” is failing miserably; it does little to correct the underlying metabolic disturbances driving obesity, trapping people in a vicious cycle of weight loss and regain. However, all hope is not lost! The ketogenic diet is emerging as a powerful, sustainable tool for weight loss in overweight and obese individuals.
A growing body of research indicates that ketogenic diets are more effective than low-fat diets for sustaining long-term weight loss in obese adults. (2, 3) Furthermore, the weight loss observed on a ketogenic diet is primarily visceral fat, the hard-to-lose fat located deep in the abdominal cavity; lean body mass, on the other hand, is preserved. (4)
A ketogenic diet may also benefit obese children. A study that placed obese children on a ketogenic diet for six months observed significant decreases in body fat, waist circumference, fasting insulin levels, and HOMA-IR, a marker used to detect insulin resistance. (5)
The ketogenic diet facilitates fat loss by increasing the efficiency of fat oxidation (the process by which fat is “burned” for energy), suppressing hunger hormones, and providing the body with plenty of satiating dietary fat and protein, thus decreasing total energy intake. (6)
For those who do not wish to stay on the ketogenic diet long term, a cyclic ketogenic diet alternated with a nutrient-dense, whole foods diet can also lead to successful long-term weight loss. (7) I’ll cover the cyclic ketogenic diet in more depth shortly.
2. Metabolic Syndrome
Over one-third of Americans have metabolic syndrome, a constellation of complications including increased blood pressure, elevated blood sugar, excess abdominal fat, and abnormal triglyceride and cholesterol levels that significantly increase one’s risk of heart disease, diabetes, and stroke. (8) The conventional treatment of metabolic syndrome typically involves cholesterol-, blood sugar-, and blood pressure-lowering medications, along with vague advice to “eat better.” Given that heart disease is still the number one cause of death in the United States, that diabetes is considered to be at epidemic proportions, and that strokes disable or kill someone every 40 seconds on average, this treatment paradigm leaves much to be desired. (9)
Fortunately, patients have an alternative—a ketogenic diet. Research indicates that a ketogenic diet improves multiple aspects of metabolic syndrome, inducing significant reductions in body fat percentage, BMI, hemoglobin A1c levels, blood lipids, and blood pressure. (10, 11, 12) The ketogenic diet produces these beneficial effects by reversing the pathological processes underlying metabolic syndrome, including insulin resistance and chronic inflammation.
3. Type 2 Diabetes
Ketogenic diets represent a far more effective strategy for managing type 2 diabetes than the American Diabetes Association’s high-carb, low-fat dietary guidelines. Unlike the ADA’s guidelines, a ketogenic diet significantly reduces blood sugar, hemoglobin A1c levels, waist circumference, and triglycerides in diabetic individuals. (13) Most importantly, research indicates that the diet is sustainable for diabetic patients and that the beneficial changes can be maintained over the long term. (14)
4. Polycystic Ovary Syndrome (PCOS)
Between 5 and 10 percent of women in the United States have polycystic ovary syndrome (PCOS), a disorder characterized by insulin resistance, menstrual irregularities, hyperandrogenism, overweight, and obesity. (15) A ketogenic diet improves fertility in women with PCOS by improving insulin resistance, promoting weight loss, and inducing ovulation. (16)
5. Neurodegenerative Diseases
A great deal of exciting research is emerging regarding the application of a ketogenic diet in the treatment of neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease. (17) Neurodegenerative diseases are characterized by brain insulin resistance, a condition that starves neurons of the glucose they normally need to function correctly. Scientists have found that ketones are an excellent alternative fuel for the insulin-resistant brain. In addition, ketones reduce brain oxidative stress and mitochondrial dysfunction, two significant factors in the neurodegenerative disease process.
Animal research indicates that a ketogenic diet reduces levels of brain amyloid-beta, a misfolded protein that contributes to Alzheimer’s disease, while also restoring mitochondrial function and improving learning and memory. (18, 19, 20) Although fewer studies on a ketogenic diet have been done in humans with Alzheimer’s disease, a recent trial found a ketogenic diet to be both safe and effective for mild Alzheimer’s disease. (21)
Preclinical research suggests that a ketogenic diet may also benefit those with Parkinson’s disease. In animal models of Parkinson’s, a ketogenic diet improves motor function, and in humans with Parkinson’s, it improves nonmotor symptoms such as daytime sleepiness and cognitive disorders. (22, 23) While more research is needed, a ketogenic diet may be a powerful intervention well worth a try for both Alzheimer’s and Parkinson’s patients.
6. Traumatic Brain Injury and Epilepsy
Traumatic brain injury (TBI) is an injury caused by a blow, bump, or jolt to the head that significantly impairs brain function. TBI is common in military personnel, car accident survivors, and athletes involved in contact or high-risk sports. If left untreated, TBI can cause severe impairments in thinking, memory, and emotional regulation. Interestingly, a ketogenic diet may be an effective strategy for reducing the harmful effects of TBI.
A ketogenic diet promotes healing of the brain following TBI by increasing the activity of genes genes involved in energy metabolism, stimulating the generation of new mitochondria, and inhibiting the production of damaging reactive oxygen species in the brain. (24) In animal models of TBI, a ketogenic diet reduces cerebral edema and neuronal cell death while improving behavioral outcomes. (25, 26) While individual success stories of people using a ketogenic diet for TBI are easy to find on the internet, formal clinical trials are still needed.
Compared to TBI, the amount of scientific literature documenting the beneficial effects of a ketogenic diet for epilepsy is vast. The ketogenic diet was first introduced as a therapy in the 1920s, when doctors learned it could successfully treat seizures in children with refractory epilepsy. (27) Interest in the ketogenic diet waned when antiepileptic drugs were introduced in the 1960s and ’70s; however, the ketogenic diet has experienced a recent resurgence in popularity in the epilepsy community, particularly among those suffering from drug-resistant epilepsy.
The ketogenic diet exerts antiepileptic effects by improving energy metabolism in the brain and reducing brain oxidative stress. Fascinating new research suggests that the antiseizure effects of the ketogenic diet are also mediated by modulation of the gut microbiota. (28) Consumption of a ketogenic diet increases the levels of bacteria that produce GABA, the brain’s primary inhibitory neurotransmitter; this shifts neurotransmission towards inhibition rather than excitation, thus preventing neuronal hyperexcitability and seizure onset.
7. Digestive Disorders
A high carbohydrate intake can exacerbate irritable bowel syndrome (IBS) and gastroesophageal reflux disease (GERD) by feeding opportunistic and pathogenic bacteria in the gut. (29) These microbes ferment dietary carbohydrates, producing gases that increase intraabdominal pressure, a driving force behind acid reflux and GERD. The gas manufactured by these bacteria also contributes to bloating, abdominal pain, and diarrhea in IBS.
How can a ketogenic diet help with IBS and GERD? By significantly reducing dietary carbohydrate load, a ketogenic diet provides less fermentable substrate for gut bacteria, reducing the amount of gas produced in the small intestine. Several small studies indicate that a ketogenic diet improves abdominal pain, stool frequency, and reflux in patients with IBS-D and GERD, respectively. (30, 31) However, it is important to note that the long-term effects of a low-fermentable-carbohydrate diets, including the ketogenic diet, on gut bacteria remain to be seen. Our beneficial gut bacteria also require fermentable carbohydrates to survive, so it’s possible that the ketogenic diet could reduce their numbers. This is why I highly recommend following a cyclic ketogenic diet rather than a long-term, strict ketogenic diet. I’ll provide more information on that topic shortly.
8. Skin Conditions
A ketogenic diet may seem like an unlikely approach for treating skin issues. However, keto addresses several of the physiological mechanisms underlying dermatological issues, particularly acne and psoriasis, and can therefore help people correct the root cause of their skin conditions.
Insulin is a crucial driver of acne due to its effects on hormones, sebum production, and inflammation. By reducing insulin, the ketogenic diet may correct hormone imbalances, excessive sebum production, and inflammation, thereby alleviating acne. (32)
High blood sugar promotes psoriasis by increasing levels of a protein that causes inflammation. A ketogenic diet corrects hyperglycemia and may lower the level of this protein, resulting in the amelioration of psoriasis. (33)
9. Some Forms of Cancer
Some of the most exciting research on the ketogenic diet pertains to its applications in the treatment of cancer. A rapidly growing collection of animal studies indicates that the ketogenic diet has anticancer effects in malignant glioma, neuroblastoma, prostate cancer, and colon cancer. (34) In humans, a ketogenic diet has been found to work synergistically with antineoplastic agents in the treatment of malignant glioma, a common primary brain tumor that is notoriously difficult to treat. (35) Several small studies indicate that the ketogenic diet improves body weight and blood profiles while reducing a marker for tumor progression, TKTL1, in patients with breast, prostate, colon, melanoma, and lung cancers. (36, 37)
The ketogenic diet exerts anticancer effects by inducing a metabolic shift in malignant tissues that promotes apoptosis (self-programmed death) of cancer cells, inhibiting angiogenesis (the growth of new tumor-supporting blood vessels), reducing oxidative stress and inflammation, suppressing mTOR (a protein in humans involved in the regulation of cell growth and regeneration), and increasing the sensitivity of certain cancer cell types to chemotherapy. (38)
Since a ketogenic diet can induce weight loss, clinicians should take care to ensure that adequate calories are consumed to inhibit undesirable weight loss in cancer patients.
It is crucial to recognize that not all forms of cancer will respond to a ketogenic diet.
Research suggests that cancer cells with low levels of particular enzymes (the ketolytic enzymes 3-hydroxybutyrate dehydrogenase and succinyl CoA 3-oxoacid CoA transferase) are more susceptible to the anticancer effects of a ketogenic diet. Screening a patient’s cancer cells for these enzymes may represent a valuable strategy for determining whether a ketogenic diet may be of use. (39)

Who Should Avoid a Ketogenic Diet?
The ketogenic diet is not appropriate for everyone. If you fit any of the descriptions listed below, then a ketogenic diet may have a negative impact on your health.
You Have a Genetic Condition That Affects Fatty Acid Metabolism
Since fats are consumed in large quantities on a ketogenic diet, any genetic condition that impairs fatty acid metabolism precludes the use of this diet. If you have primary carnitine deficiency, pyruvate carboxylase deficiency, or any of the other genetic conditions listed here, a ketogenic diet is absolutely contraindicated.
You’re Pregnant or Breastfeeding
While a growing fetus can utilize ketones to an extent, it still requires a steady glucose supply to support normal growth, including crucial brain development. Reduced glucose availability caused by a maternal ketogenic diet may have long-term adverse effects on infant health, including abnormal growth patterns and alterations in brain structure. (40) If you are pregnant and struggling with blood sugar issues, a low-carbohydrate diet that includes moderate amounts of nutrient-dense carbohydrates, such as fruit and starchy tubers, is a safer choice than a ketogenic diet.
You Have Gallbladder Disease or No Gallbladder
The body needs bile to break down and digest dietary fat, and the gallbladder is responsible for storing bile before its release into the small intestine. Removal of the gallbladder and gallbladder disease cause fat malabsorption and may make it difficult to follow a ketogenic diet. If you have had your gallbladder removed or have existing gallbladder disease, consult with your doctor before trying a ketogenic diet.
You’re Suffering from Kidney Disease or Kidney Stones
While preliminary research suggests that a ketogenic diet may benefit chronic kidney disease patients, caution is advised in those with kidney disease or kidney stones. (41) If you have a kidney condition, consult with your doctor before starting a ketogenic diet.
You Have HPA Axis Dysfunction and High Levels of Stress
A ketogenic diet has been observed to raise cortisol, the body’s primary stress hormone. If you struggle with high levels of stress or HPA axis dysfunction, a ketogenic diet may push your stress-response system into overdrive and cause burnout. A diet that includes a moderate intake of carbohydrates is typically a better fit for those with high-stress lifestyles or HPA axis dysfunction.
You’re a Hyper-Responder to Dietary Cholesterol
While dietary saturated fat and cholesterol do not impact blood cholesterol levels in most people, they may raise total and LDL cholesterol in a subset of the population referred to as “hyper-responders.” If you are a hyper-responder (this is something you’ll need to determine with the help of your doctor), I recommend following a Mediterranean Paleo-style diet, an approach that is lower in fat and higher in Paleo-friendly carbohydrates, rather than a ketogenic diet.
You’re an Athlete
If you participate in exercise that involves explosive movements such as jiujitsu, mixed martial arts, CrossFit, or even some rigorous forms of dance, you may benefit from a moderate carbohydrate intake rather than a ketogenic diet. Explosive movements draw on your muscles’ glycolytic capacity, which is powered by glucose from dietary carbohydrates. Endurance athletes, on the other hand, may thrive on a ketogenic diet because their respective activities can be adequately fueled by fatty acid oxidation and ketones.

How Long to Follow the Ketogenic Diet
The ideal keto diet time frame must take into account both nutritional ketosis and fat adaptation. Ketosis means your body is experiencing an acute lack of glucose and is therefore producing ketone bodies for energy. Fat adaptation, on the other hand, means your body has become adapted to burning fat for fuel.
When you first embark on a ketogenic diet, your goal is to be in nutritional ketosis consistently. Over time, as you train your body to function on fewer carbohydrates, you may enter the fat adaptation phase. While ketosis can be achieved after just a few days of the diet, at least three to four weeks of strict adherence to the diet is required in order to reach the fat adaptation state. This is also the time frame during which you’ll likely begin to notice benefits of the diet.
While some keto proponents advocate following the diet long term, a cyclic ketogenic diet may be a healthier choice.
A cyclic ketogenic diet involves carb-loading one to two days of the week, followed by a standard low-carb ketogenic diet the remaining days of the week. Cyclic keto has many benefits—it allows the body to enter a state of ketosis regularly while also satisfying carb cravings, improving sleep, and promoting a healthier balance of gut bacteria.

The Three-Step Process to Starting Keto
Step 1: Find Your Macronutrient Ratio
The goal of a ketogenic diet is to transition the body’s primary fuel supply from carbohydrate to fat, creating a state of nutritional ketosis and, eventually, fat adaptation. The degree to which dietary carbohydrates need to be reduced to reach nutritional ketosis varies from person to person. Finding the optimal macronutrient ratios for getting your body into ketosis requires some self-experimentation. I recommend playing around with the ranges listed below to find the ones that work best for you.
Possible macronutrient ranges for keto:
60 to 75 percent of calories from fat
15 to 30 percent of calories from protein
5 to 10 percent of calories from carbohydrates
I would like to emphasize that the super-high-fat, low-protein version of keto promoted by some keto advocates is not necessary for most people to obtain the benefits of keto.
Proponents of the super-high-fat, low-protein approach argue that protein kicks the body out of ketosis by supplying amino acids for gluconeogenesis (simply put, turning non-carbs into fuel); however, research indicates that the impact of dietary protein on gluconeogenesis and glucose flux is nearly negligible, making this argument irrelevant.

(42) In my practice, we have found that usual protein intakes (15 to 20 percent of calories) do not have appreciable effects on blood ketone levels. Besides, a super-high-fat, low-protein diet typically has more drawbacks than benefits—it may cause weight gain, muscle loss, fatigue, and chronic hunger. Don’t be afraid of including plenty of protein in your ketogenic diet; protein is a powerful tool that will satiate your appetite while facilitating fat loss and preventing muscle loss.
Step 2: Don’t Count Calories
I don’t recommend counting calories on the keto diet. Tracking your macronutrients, on the other hand, can be helpful. Try using an app for journaling your food intake and obtaining your ratios of macronutrients. I recommend the Carb Manager Keto Diet App.
Step 3: Regularly Test Your Ketones
To determine whether you’re in ketosis and what degree of ketosis you’re in, test your ketones each morning. Blood ketone testing is the most accurate method—I do not recommend breath or urine ketone monitoring. In our practice, we recommend the Precision Xtra Blood Glucose Meter Kit, which can be purchased on Amazon (you can buy test strips for this meter in bulk on eBay for a lower cost). Keto Mojo is another good meter with affordable test strips.
If your ketone value is above 0.5 mmol/L first thing in the morning, you’re in ketosis. However, a range of 0.7 to 2.0 mmol/L is optimal for most people. If your value is above 3.0 mmol/L, you may not be eating enough and/or should consider adding some carbohydrates back to your diet. However, in the long run, your goal should not be a specific number on the ketone meter, but an improvement in your symptoms.

13 Tips and Tricks to Help You Follow a Ketogenic Diet
Following a ketogenic diet can take some work and planning. Here are some tips and tricks to help you get into ketosis faster.
1. Eat Enough Calories and Protein
Failing to consume enough calories on a keto diet can cause fatigue and insomnia, while an insufficient protein intake promotes weight gain and muscle loss. When you first begin a keto diet, it can be helpful to track your food intake with an app such as Carb Manager Keto Diet App; this will allow you to visualize your macronutrient intake and ensure that you don’t undereat calories or protein. As I mentioned earlier, a low-protein intake is not required to obtain the benefits of keto. A sufficient protein intake (15 to 30 percent of total calories) suppresses hunger and, in most people, does not affect blood ketone levels. (43)
2. Add Supplemental Fat
Fat is the primary source of fuel on a ketogenic diet, and supplementing with specific types of fat, particularly coconut oil and medium-chain triglyceride (MCT) oil, can help you get into ketosis faster. MCT oil is unique in that it increases ketone levels in a linear, dose-dependent manner and allows for the induction of ketosis with lower amounts of total fat in the diet. (44)
If you are a hyper-responder to dietary fat and cholesterol, you may need to restrict your intake of saturated fats on keto. Instead, focus on fats such as olive oil, avocados, fatty fish, nuts, and seeds.
3. Supplement
L-leucine is a ketogenic amino acid, meaning it can be used to make ketones. Supplementing with L-leucine may help you get your body into ketosis faster.
Exogenous ketones are ketones that are ingested as a nutritional supplement. They elevate blood ketone levels but may inhibit the body’s own process of ketogenesis. (45) I consider exogenous ketones an advanced strategy for those who have already nailed down the basics of keto.
4. Drink Apple Cider Vinegar
Consuming apple cider vinegar before meals not only assists digestion but may also promote ketone production due to its content of acetic acid, a naturally occurring ketogenic compound. Try adding a tablespoon or two to water and drinking before you eat your meal.
5. Increase Your Salt Intake
The body excretes more salt on a keto diet than on a standard diet due to reductions in insulin, which normally promotes a certain degree of water retention. Once you’re in ketosis, add an extra three to five grams of Himalayan, sea, or Redmond Real salt to your diet every day. (Five grams is about one teaspoon, but that may vary depending on the type of salt and the size of the grain.)
6. Eat More Magnesium and Potassium
In addition to sodium, levels of magnesium and potassium can also drop on a ketogenic diet due to its dehydrating effect on the body. Make sure to eat plenty of magnesium- and potassium-rich foods. Some of the best keto-friendly sources of magnesium are dark leafy greens, nuts and seeds, and cacao. Keto-friendly potassium sources include spinach, kale, avocados, and mushrooms.
7. Avoid Artificial Sweeteners
Artificial sweeteners such as saccharin (Sweet’N Low), aspartame (NutraSweet, Equal), and sucralose (Splenda) are quite popular among low-carb dieters. However, concerning new research indicates that artificial sweeteners have adverse metabolic effects and may work against your keto efforts by disrupting your gut microbiota and inducing insulin resistance and weight gain. (46, 47) If you want to use a non-caloric sweetener, I recommend either stevia or monk fruit sweetener.
8. Stock Up on Keto-Friendly Snacks
Keep keto-friendly snacks on hand so that when hunger strikes, you have healthy food at the ready; this strategy will help prevent you from falling off the keto wagon and reverting to high-carb snack foods. Nuts and seeds, coconut butter, grass-fed beef jerky, and hard-boiled eggs make for easy, portable keto snacks.
9. Try Intermittent Fasting
Intermittent fasting, an eating style in which you eat within a specific period each day and fast the rest of the time, is a great way to reduce the amount of time your body needs to enter nutritional ketosis. (48) Intermittent fasting accelerates the time to ketosis by keeping insulin levels low and raising ketone levels. If you’re new to intermittent fasting, start by limiting your eating to an eight- to 10-hour window each day and fasting for the remaining 14 to 16 hours of the day (and night).
10. Decrease Your Stress
Stress is an underappreciated but significant impediment to achieving success on a ketogenic diet. High stress elevates cortisol, which stimulates the generation of glucose (gluconeogenesis) in the liver. Gluconeogenesis raises blood glucose and reduces ketone levels; together, these effects make it difficult to enter ketosis.
Try these strategies for reducing your stress:
Set aside time for rest, ideally away from your smartphone and computer
Cut down on commitments
Get plenty of sleep
Start a mindfulness practice such as meditation
Spend time in nature
Spend quality time with friends and family
11. Prioritize Sleep
Inadequate sleep will rapidly derail your keto efforts by increasing your blood sugar and levels of stress hormones. Getting eight to nine hours of high-quality sleep per night should be a priority. Maintain a regular bedtime schedule and practice sleep hygiene strategies such as keeping your bedroom completely dark at night, lowering the ambient temperature to around 67 degrees Fahrenheit, and avoiding blue light exposure a couple of hours before bed with blue light-blocking glasses.
12. Exercise
Frequent exercise depletes glycogen stores, causing your body to turn to fat for energy; this means that regular exercise can help you get into ketosis faster. Some people experience a reduced capacity for exercise upon starting keto; in this case, engaging in longer durations of low-intensity activity, such as walking, cycling, or swimming, can help you get into ketosis without causing undue fatigue.
13. Drink Plenty of Water
Within the first few days of starting a ketogenic diet, you may experience a significant loss of water weight. This occurs primarily because glycogen stores in muscle are gradually being reduced, and glycogen causes retention of water. To ensure that you don’t become dehydrated on keto, drink half your weight in ounces of filtered water every day.

What to Expect When You’re on the Keto Diet
As your body gets used to keto, you may experience some uncomfortable side effects. Here’s what to expect.
The “Keto Flu”
The first few days of keto can be difficult as your body adjusts to a low carbohydrate intake; you may experience symptoms such as brain fog, headache, insomnia, irritability, and digestive issues. These symptoms are commonly referred to as the “keto flu” and are caused by the glycogen loss, low insulin levels, and dehydration that frequently occur when you suddenly cut back on carbs. Know that these symptoms will pass, especially if you make sure to drink plenty of water, replenish your electrolyte levels, and eat sufficient protein and calories. At the most, it may take a couple weeks for the keto flu to subside, but for most people, this uncomfortable period passes within a few days.
Constipation
Constipation is a common complaint for keto dieters. There are several reasons why you may experience constipation:
You’re not eating enough fiber. It’s easy to eat lots of meat, cheese, and oils on a ketogenic diet at the expense of optimal fiber intake. Be sure to eat plenty of colorful non-starchy vegetables (broccoli, cauliflower, kale, bell peppers, mushrooms) because the fiber in these foods will keep things moving through your digestive tract.
You may need more water. As I mentioned earlier, people typically experience body water loss when starting a ketogenic diet. Your digestive tract needs water to keep fecal matter soft and moving through your intestines; if you are dehydrated, constipation is likely.
Try resistant starch. Resistant starch passes through the small intestine intact and therefore doesn’t count as a dietary carbohydrate. Instead, it travels to your large intestine, where it’s used to feed beneficial gut bacteria. Try adding a teaspoon of resistant starch, such as raw potato starch or green banana flour, to your keto smoothie each day to keep your gut happy.
Take a probiotic and eat fermented foods. The beneficial bacteria in probiotics and fermented foods help prevent sluggish digestion and promote healthy bowel function.
Reduced Thyroid Function
Research has found that a ketogenic diet decreases levels of T3, the body’s active thyroid hormone. (49) Unfortunately, this means a ketogenic diet may not be optimal for those with pre-existing hypothyroidism. If you have hypothyroidism and want to proceed with a ketogenic diet, consult with your doctor first because you may need thyroid support.
Elevated Cortisol
Research has indicated that a ketogenic diet raises the stress hormone cortisol to increase energy levels in the face of reduced carbohydrate availability. However, it is still up for debate whether this increase in cortisol is harmful or innocuous. Nonetheless, I recommend taking extra care to manage your stress while on a ketogenic diet. Getting plenty of sleep, exercising, and engaging in a regular stress-reduction practice can help you keep your baseline stress levels low and reduce the potential for chronically elevated cortisol.

Liraglutide can improve fatty liver damage as well as blood sugars

Adapted from Glucagon like peptide-1 receptor agonists for the management of obesity and non-alcoholic fatty liver disease: a novel therapeutic option. 

Gauri Dhir and Kenneth Cusi  Endocrinology/Metabolism Review Volume 66 Issue 1 2018

Obesity is a major risk factor for type two diabetes and a cluster of metabolic factors that lead to poor cardiovascular outcomes.  The amount of fat stored in the liver tissue closely mirrors insulin resistance and metabolic health.

Non alcoholic fatty liver disease (NAFLD) is now the commonest form of liver disease in the western world and can lead progressively to non alcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma.

NAFLD is present in two thirds of obese people and promotes type two diabetes.  NASH is present in half of these. NAFLD is expected to become the most common cause of liver transplantation by 2020.

Pioglitazone and the newer drugs such as Liraglutide (Victoza) can be used, as well as various dietary therapies.

If a weight loss of 10% can be achieved, there is a significant improvement in the inflammatory process that results in cell death and fibrosis in NASH. But weight loss is difficult to achieve and maintain.  Pioglitazone can improve  NASH in two thirds of non- diabetic patients and by around half in those with diabetes or pre-diabetes.  Vitamin E has also been shown to have some success in non diabetic patients.

Liraglutide and drugs of the same class affect insulin secretion in response to meals, beta cell proliferation, inhibition of glucagon secretion, delayed gastric emptying, and making you feel fuller with less to eat.

These effects result in worthwhile clinical outcomes in overweight or obese patients whether they have diabetes or not. Body weight is reduced by at least 5% in 30% of patients and by at least 10% in 30% of patients. Over three years this can result in complete remission of the diabetes or pre-diabetes in 30% of the patients. Cardiovascular outcomes are also improved.

Triglyceride accumulation in the liver cells is the mechanism that has been recently shown to cause insulin resistant adipose tissue.  After 48 weeks of high dose Liraglutide (1.8 mg a day), resolution of NASH was seen on biopsy samples in 39% of the treated group compared to 9% in the placebo group.

The main side effects are nausea and diarrhea.  There could possibly be more gallstone development but no increase in pancreatitis.

Obesity makes asthma particularly difficult to control

From British Thoracic Society Winter Scientific Meeting December 2017 London

Researchers have demonstrated that diet induced obesity leads to the development of airways hyper-reactivity through the interplay of an immunological and metabolic pathway.

Resultant asthma can affect children as well as adults. Unfortunately obesity associated asthma responds poorly to standard asthma medications including steroids and can result in more hospitalisation and a reduced quality of life.

The most effective obesity treatment is probably bariatric surgery to achieve sustained weight loss. In contrast dietary management and drugs are far less effective.