Should you get tested for coeliac?

From Allergy and Autoimmune Disease for Healthcare Professionals October 9 2019

Apparently 70% of people who have coeliac have yet to be tested for it.

Who may have it?

4.7% of those with irritable bowel syndrome.

20% of those with mouth ulcers.

8% of infertile couples.

16% of type one diabetics.

7.5% of first degree relatives of people with coeliac.

About 50% of people who are diagnosed have iron deficiency diagnosis  at the time of coeliac diagnosis.

Other people who need to be tested may have:

Pancreatic insufficiency

Early onset osteoporosis or osteopenia

vitamin and mineral deficiencies

gall bladder malfunction

secondary lactose intolerance

peripheral and central nervous system disorders

Turner’s syndrome

Down’s syndrome

Dental enamel defects

persistent raised liver enzymes of unknown cause

peripheral neuropathy or ataxia

metabolic bone disorders

autoimmune thyroid disease

unexplained iron, vitamin D or folate deficiency

unexpected weight loss

prolonged fatigue

faltering growth

second degree relative with coeliac disease

My comment: I had years of  the mouth ulcers, iron deficiency anaemia and irritable bowel symptoms which all resolved completely on a wheat free diet. The problem is that if I did want tested I would need to go back on wheat for a minimum of six weeks to give my antibodies a chance to build up sufficiently to test positive.  Thus, best to get a test BEFORE you go on a wheat free diet.

 

 

Relax your hand when you get a blood sample taken

From BMJ 2 Feb 19 by J Ian Robertson and M Gary Nicholls

Sometimes neither patient or clinician pay attention to what happens during venepuncture. But clenching the hand before or during the procedure can cause blood potassium levels to rise markedly. This effect is increased if a tourniquet is used.

Therefore if possible it is best to keep the hand relaxed especially if potassium levels are considered critical. Other chemistry measurements that are adversely affected include  calcium, aspartate amino transferase, chloride, creatine kinase, magnesium, sodium and phosphate.

These effects are widely unrecognised. Since no one wants a repeat blood test,  remember this at your next appointment.

 

High dose Vitamin D improves cardiovascular health markers

Adapted from UK Medical News 17 July 2018

Several different health measures, all which improve your cardiovascular outcomes, have been found to result from high dose vitamin D supplementation. You are likely to need to take at least 4,000 iu a day though, depending on how much extra sunshine you are exposed to regularly.

A meta-analysis of 81 randomised controlled trials looked at almost one thousand patients randomised to taking supplements or to a control group who did not. The active and control groups were both roughly 5,000 each.  The durations of the trials varied but averaged out at ten months. The doses ranged from 400 iu a day to 12,000 iu a day. The average taken was 3,000 iu a day.

The outcomes were related to the blood level of vitamin D achieved. Levels had to be over 86 nmol/L to get benefits. You need to take over 4,000 iu a day to get vitamin D concentrations of 100 nmol/L or more.  My comment:This does mean that the minimum levels advised by the Scottish Chief Medical Officer last year are way too low to see the benefits discussed here.

So what extra benefits do you see?

lower systolic and diastolic blood pressure.

lower high sensitivity C reactive protein.

lower serum parathyroid hormone.

lower triglycerides.

lower total cholesterol.

lower low density lipoprotein.

high density lipoprotein increased.

All benefits were numerically small but did reach statistical significance. Cardiovascular outcomes were not measured directly, only blood markers and blood pressure.

Mirhosseini N et al. Vitamin D Supplementation. Serum 25(OH)D Concentrations and cardiovascular disease risk factors: A systematic review and meta-analysis. Front Cardiovasc Med. 2018 July 12.

 

 

 

 

EC-Funded Project Researches T1 Diabetes Cure

Have you heard of the LSFM4LIFE project? This week, I received an email about European Commission funded work into a potential permanent cure for type 1 diabetes.

The base of the research is a cellular therapy, growing human pancreas organoids (mini organs) from adult stem cells. The organoid of the pancreas then produces insulin, freeing type 1s from daily insulin injections.

Currently, the project is at the research stage. It involves eight partner teams from six different countries who are working to develop tools and technologies for cell-based therapy. The partners come from academia and industry, and include Goethe University, the University of Cambridge, InSphero and Sparks and Co.

Incidence of type 1 diabetes is increasing by 3 to 4 percent every year, especially among children.

You can read more about the project here: https://lsfm4life.eu/lsfm4life-in-depth/ and there’s a quick explanation of it on YouTube here.