From Univadis Nakhleh A et al. Journal of Diabetes Complications 18th April 2020
It is well known that patients on Flozins are much more prone to urine infections and thrush due to the extra sugar in the urine which is excreted by taking these drugs, also known as SGLT2 inhibitors.
An Israeli study of over 6 thousand women with type two diabetes sought to clarify who was more or less likely to be affected by this very annoying problem.
They found that those most likely to get urine infections were:
Women who had existing gastro intestinal problems
Women who had been taking oral oestrogen in the form of the contraceptive pill or HRT
Women less likely to be affected:
were older (over 70)
had prior existing chronic kidney disease
My comment: From my GP experience I found that these drugs were highly effective and generally well tolerated. A few patients were indeed badly affected by recurrent urine infections and thrush and had to discontinue the drugs.