Heri’s Health Points: Why a good sleep should be your priority

When improving wellness, better sleep should a priority vs nutrition, fitness programs or prescription

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Too often, the focus is on being more active, look into new diets or exotic holidays.

These would bring energy, improve strength or cure depression.

The cornerstone of a sustainable and healthy body is quality sleep.

Many brush off sleep. Society or human groups do not value or celebrate when you take a good night sleep. Nobody gets alarmed when you miss a night sleep. Even, all-nighters marathons are celebrated as a proof of motivation and dedication.

Yet, lack of sleep or sleep deprivation deregulates main body functions : impaired brain activity, cognitive dysfunction, weakened immune response, hormonal system dysfunction, poor muscle repair, risk of Type 2 diabetes, higher blood pressure, weight gain, heart disease and so on.

This means quality sleep must be a priority, above nutrition, leisure, physical activity and even work.

Here’s my sleeping plan, let me know if it is good for you:

  • If I do not feel well, I try to see first if I had quality sleep recently, before thinking of stress, nutrition or anything else.
  • I close negative emotions.
  • If I have not been sleeping well recently, I make sure not to overstrain. That means in order : not taking any caffeine (coffee or tea) 5 hours before sleep, no strenuous exercise, no blue light 3 hours before sleep, lower home temperature 2 hours before sleep, massage 1 hour before sleep, camomille tisane 1 hour before sleep.
  • Moderate exercise such as 30mn walking at a good pace at 5pm can improve sleep.
  • Move or change sleeping conditions if not optimal. That can include moving out or thinking about the sound environment.
  • Activity trackers and sleep apps can help measure good sleep and give insights. However, trackers do not improve sleep quality and impact is limited.

References:

  • D. J. Bartlett, N. S. Marshall, A. Williams, R. R. Grunstein. June 2007. Sleep health New South Wales: chronic sleep restriction and daytime sleepiness. Internal Medecine Journal
  • June J. Pilcher PhD & Elizabeth S. Ott BS. March 2010. Relationships Between Sleep and Measures of Health and Weil-Being in College Students: A Repeated Measures Approach. Journal of Behavioral Medecine.
  • Hideki Tanaka, Shuichiro Shirakawa. May 2004. Sleep health, lifestyle and mental health in the Japanese elderly. Journal of Psychomatic Research
  • Making sleep a priority – Daily Health Points

Want to feel better? Write down your thoughts and then decide what to do with them.

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In experiments with students it has been found that writing down your thoughts, in your own handwriting, can help you feel more positive, provided you fling away your negative ruminations and keep your positive ones close.

Professor Richard Petty of Ohio State University Psychology department collaborated with colleagues in Spain and tested 83 high school students.

Spending time looking at your negative thoughts make you feel bad about yourself. Throwing out negative and positive thoughts immediately has little impact on you, but putting your positive thoughts in your pocket or purse and referring to them later, has all round positive effects on your mood and future behaviour.

Computerised lists that were either retained or deleted had some effect too, but simply imagining that you had deleted them didn’t work.

(Reported in Human Givens Volume 1 2013 from Brinol P et al, Treating thoughts as material objects can increase or decrease their impact on evaluation. Psychological Science, 24, 1, 41-7)

My comments: this little tip could be very helpful. I know that people who keep journals tend to be more depressed than average. This could be partly due to the introspective nature of journal writing but also perhaps because negative thoughts or events can be reinforced by referring to them or even just carrying them around! 

For avid diary writers perhaps they should keep two journals,   one only keep the good events thoughts and another much smaller book that can be thrown in the trash every so often, preferably quite frequently.

It could also help when you want to achieve something.  Put all of the pros in one list, all the cons on the other, and simply toss out the cons!

 

Margaret Coles: Invite this Physiotherapist into your home

At  www.movingtherapy.co.uk. you can find Margaret Cole’s free educational resource to help your health and well being.

home-physio

Margaret worked as a community physiotherapist and when she retired she decided to put her knowledge and experience to good use. She produced videos covering a lot of different situations that you can face regarding your physical and mental states and has put them on the site. She also gives advice on how to lose weight.   People from all over the world have visited the site since 2011.

NHSinform Scotland and her local authority also promote the site.

 

 

Eric Barker: Meditation for the distracted

meditation.jpg

Welcome to the Barking Up The Wrong Tree weekly update for September 4th, 2016.

Neuroscience Of Meditation: How To Make Your Mind Awesome

Click here to read the post on the blog or keep scrolling to read in-email.

So is meditation just another fad that pops up from time to time like bell-bottom jeans? Nope. Research shows it really helps you be healthier, happier and even improves your relationships.

From The Mindful Brain:

The MBSR program brought the ancient practice of mindfulness to individuals with a wide range of chronic medical conditions from back pain to psoriasis. Kabat-Zinn and colleagues, including his collaborator Richard Davidson at the University of Wisconsin in Madison, were ultimately able to demonstrate that MBSR training could help reduce subjective states of suffering and improve immune function, accelerate rates of healing, and nurture interpersonal relationships and an overall sense of well-being (Davidson et al., 2003).
And it’s not some magical mumbo-jumbo at odds with the science of psychology. In fact, it is psychology. William James, one of the fathers of modern psych, once said this…

From Thoughts Without A Thinker:

While lecturing at Harvard in the early 1900s, James suddenly stopped when he recognized a visiting Buddhist monk from Sri Lanka in his audience. “Take my chair,” he is reported to have said. “You are better equipped to lecture on psychology than I. This is the psychology everybody will be studying twenty-five years from now.”
Last week I posted about the neuroscience of mindfulness. Long story short (and grossly oversimplified): the right side of your brain sees things literally. The left side interprets the data and makes it into stories.

But Lefty screws up sometimes. His stories aren’t always accurate. As the old saying goes, “the map is not the territory.” When you listen too much to Lefty’s stories and not enough to the raw data from the right brain, you can experience a lot of negative emotions. A big chunk of mindfulness is keeping Lefty under control. (For the full story, click here.)

But where does meditation fit into all this? What does sitting cross-legged and focusing on your breath have to do with Lefty, the brain and eternal happiness?

And how the heck do you meditate properly? Maybe you’ve tried it and only ended up taking an unexpected nap, or getting horribly bored, or feeling like your brain is noisier than the front row of a death metal concert.

Let’s look at the science and cut out the magic and flowery language. We’ll hit the subject with Occam’s Chainsaw and get down to brass tacks about what meditation really is, why it works, and how to do it right.

Time to put your thinking cap on…

What The Heck Is Meditation?

A good quick way to see it from a neuroscience perspective is as “attention training.” (You know, attention. That thing none of us have anymore.)

But what the heck does attention have to do with happiness, stress relief and all the other wonderful things meditation is supposed to bring you?

Paul Dolan teaches at the London School of Economics and was a visiting scholar at Princeton where he worked with Nobel-Prize winner Daniel Kahneman. Dolan says this:

Your happiness is determined by how you allocate your attention. What you attend to drives your behavior and it determines your happiness. Attention is the glue that holds your life together… The scarcity of attentional resources means that you must consider how you can make and facilitate better decisions about what to pay attention to and in what ways.
And Harvard professor Daniel Gilbert, author of Stumbling on Happiness, did research showing that “a wandering mind is not a happy mind.” We want to focus on what the right side of the brain is giving us and get free from Lefty’s endless commentary.

When Lefty gets going with his ruminating, he’s much more likely to end up feeding you negative stories than positive ones. You’re happier when your attention is more focused on the concrete info your right brain is feeding you: the “here and now.” That’s all that “being in the moment” stuff you hear about.

So improving your attention is like dog obedience training for Lefty. When you can keep your attention on the right brain data and learn to disengage from Lefty’s running commentary you stress less, worry less and get less angry.

Is meditation powerful enough to overcome that often critical, cranky voice in your head? Yeah. It was even able to improve attention skills in people with ADD.

From The Mindful Brain:

At the UCLA Mindful Awareness Research Center, we recently conducted an eight-week pilot study that demonstrated that teaching meditation to people, including adults and adolescents with genetically loaded conditions like attention-deficit/hyperactivity disorder, could markedly reduce their level of distraction and impulsivity.
(To learn the four rituals neuroscience says will make you happy, click here.)

Okay, so meditation helps you focus on good things and let go of the bad, which can help you be happier and less stressed. Makes sense. So how do you do it right?

How To Meditate

Focus your attention on your breath going in and out. Your mind will wander. Gently return your attention to your breath. Repeat. Repeat. Repeat…

That’s it. Really. That’s all you have to do. Here’s how fancy neuroscience explains what’s going on…

From The Mindful Brain:

If in mindfulness practice our mind is filled with word-based left-sided chatter at that moment, we could propose that there is a fundamental neural competition between right (body sense) and left (word-thoughts) for the limited resources of attentional focus at that moment. Shifting within mindful awareness to a focus on the body may involve a functional shift away from linguistic conceptual facts toward the nonverbal imagery and somatic sensations of the right hemisphere.
Translation: the more you pay attention to the concrete info your right brain is giving you about your breathing, the less attention you have for Lefty’s interpretations, evaluations and stories.

You’re building yourself a knob that turns down the volume on Lefty’s criticisms and ramblings.

But the process is slow. Lefty will start talking again and you need to keep returning to the breath. Over and over and over. Sound like a waste of time? Nope. Here’s that father of modern psychology again, William James…

From The Principles of Psychology:

The faculty of voluntarily bringing back a wandering attention over and over again is the very root of judgment, character and will… An education which should improve this faculty would be the education par excellence.
(To learn about the neuroscience of mindfulness, click here.)

Simple, right? Actually, I’m hesitant to call meditation “simple.” It is simple, as in “not complex.” Those instructions would fit on an index card with room for your grocery list.

But that doesn’t mean meditation is easy… You know why?

Lefty Fights Back

You try to focus on your breath and banish Lefty but he keeps storming back into the room banging a tympani drum and clashing cymbals together. He won’t shut up.

Even without any input except breathing he still keeps finding things to talk about. And he jumps from one idea to the next. You try to dismiss him but it’s like mental whack-a-mole.

This is where most people give up. Don’t. Your head is not broken and you’re not clinically insane. Buddhists have known about this problem for over a thousand years. They call it “monkey mind.”

From Thoughts Without A Thinker:

Like the undeveloped mind, the metaphorical monkey is always in motion, jumping from one attempt at self-satisfaction to another, from one thought to another. “Monkey mind” is something that people who begin to meditate have an immediate understanding of as they begin to tune into the restless nature of their own psyches, to the incessant and mostly unproductive chatter of their thoughts.
Lefty is like a puppy locked in the house by himself, tearing up the furniture until you come home from work and pay attention to him. But there’s actually a valuable lesson here…

Lefty’s ideas seem so important. But then he’s on to talking about something else. And that seems so important. But then that idea flits away and it’s replaced by another one. And then that idea evaporates and is replaced…

Remember, Lefty isn’t you. He’s merely part of you, doing his job. Your heart beats, and Lefty generates thoughts. But those thoughts — which seem so important in the moment — drift away if you don’t entertain them.

And when it comes to the bad thoughts you have, and the bad feelings those generate, this is crucial and wonderful. You can just let them slide away.

But you’re tempted to take Lefty’s hand and go down the rabbit hole wondering if you should stop meditating because maybe you left the stove on, or if now wouldn’t be a great time to watch TV or finally debate the meaning of life…

Don’t. Turn your attention back to the breath.

And Lefty will say things that worry you or make you sad. And he knows just what will get under your skin. After all, he’s in your head. He’ll play “Lefty’s Greatest Hits” which never fail to get you all worked up. Don’t take the bait.

Your normal reaction is to grab your phone, check Instagram, check email, turn on the TV or do anything to distract yourself.

But that’s how you got into this problem in the first place. You need to sit here where it’s all quiet and build that attention muscle. No Instagram. Return your attention to your breath. Again and again, despite Lefty’s wailing.

Now you can’t shove Lefty away. He’s like the world’s worst internet troll — but with psychic powers. If you engage him, you just make it worse. Thoughts don’t float away if you wrestle with them. It’s like that finger trap puzzle you played with as a kid. The more you struggle to get out of it, the tighter it gets.

Just gently turn your attention back to the breath. Yes: over and over. Build that muscle.

Or maybe Lefty isn’t fighting you at all. Maybe you’re just skull-crushingly bored by this whole meditation thing. But the truth is, you’re not bored…

Lefty is. He’s tricked you again. The voice saying, “God, this sucks. Let’s watch TV.”? That’s not you. That’s him.

What is it when you call something boring? Is it concrete data from the right brain? No. It’s an evaluation. That’s Lefty talking.

Writer and neuroscience PhD Sam Harris explains that boredom is just a lack of attention.

From Waking Up: A Guide to Spirituality Without Religion:

One of the first things one learns in practicing meditation is that nothing is intrinsically boring— indeed, boredom is simply a lack of attention.
When Lefty says he’s bored that means you need more meditation — not less. Train that attention span and shut Lefty up.

(To learn what Harvard research says will make you successful and happy, click here.)

Whether he’s banging pots and pans or trying to trick you into thinking “you” are bored, Lefty won’t shut up. How do you get him to pipe down?

The answer is quite fun. Because we’re going to get Lefty to work against himself…

Don’t Fight. Label.

Ronald Siegel, professor of psychology at Harvard Medical School, writes this about the brain: “What we resist persists.” Arguing with Lefty just keeps him talking. You cannot “force” him to shut up.

So what’s the answer? Acknowledge Lefty. And, for a second, step away from focusing on the concrete and “label” what he is saying:

Lefty: “We keep meditating and we might be late for dinner. Better stop now.”

You:Worrying.” (returns to focusing on the breath)

Lefty: “I wonder if we got any new emails…”

You:Thinking.” (returns to focusing on the breath)

This uses Lefty against Lefty. When you use the left brain to put a label on its own concerns, it’s like writing something down on a to-do list. Now you can dismiss it because it’s been noted for later.

From a neuroscience perspective, it dampens Lefty’s yapping and frees you to return your attention to your breath.

Via The Upward Spiral:

…in one fMRI study, appropriately titled “Putting Feelings into Words” participants viewed pictures of people with emotional facial expressions. Predictably, each participant’s amygdala activated to the emotions in the picture. But when they were asked to name the emotion, the ventrolateral prefrontal cortex activated and reduced the emotional amygdala reactivity. In other words, consciously recognizing the emotions reduced their impact.
In fact, labeling affects the brain so powerfully it works with other people too. Labeling emotions is one of the primary tools used by FBI hostage negotiators to get bad guys to calm down.

(To learn how meditation can make you 10% happier, click here.)

Okay, so you know how to meditate and how to overcome the biggest problem people face when doing it — Lefty’s protests. But how does meditation lead to mindfulness?

Meditation Skills + Life = Mindfulness

Daniel Siegel of UCLA’s School of Medicine says that when you practice meditation consistently it actually becomes a personality trait.

You gradually start to take that attention-focusing and Lefty-labeling and apply it during your day-to-day life.

From The Mindful Brain:

Mindful awareness over time may become a way of being or a trait of the individual, not just a practice initiating a temporary state of mind with certain approaches such as meditation, yoga, or centering prayer. We would see this movement from states to traits in the form of more long-term capabilities of the individual. From the research perspective, such a transition would be seen as a shift from being effortful and in awareness to effortless and at times perhaps not initiated with awareness.
But you can accelerate this process if you actively to try to perform it. If you’re frustrated in traffic, you can focus your attention on the beautiful, sunny day outside.

When Lefty cries, “Why does this always happen to us!” you can label his statement as “frustrated.” That’ll cool down your amygdala and put your prefrontal cortex back in charge.

You can return your attention to the sunny day around you and let his complaints slide away as they always do — if you don’t turn them into a finger trap.

Lefty gets quieter and quieter. You focus more on the good things in the world around you.

And this is how you become mindful.

(To learn more about how to practice mindfulness from the top experts in the field, click here.)

Okay, newbie meditator, we’ve learned a lot. Let’s round it up and see how mindfulness can lead to the most powerful form of happiness…

Sum Up

Here’s how to meditate:

  • Get comfortable. But not so comfortable you’re gonna fall asleep. This ain’t naptime.
  • Focus on your breath. You can think “in” as your breath goes in and “out” as your breath goes out if it helps you focus.
  • Label Lefty. When Lefty brings the circus to town in your head, use a word to label his chatter and dampen it.
  • Return to the breath. Over and over. Consistency is more important than duration. Doing 2 minutes every day beats an hour once a month.

What makes us happier than almost anything else? The research is pretty clear: relationships.

But winning the war with Lefty is so internal, right? It’s all about you. (And him, I guess… But he is you… So it’s still about you.) Does that mean meditation and mindfulness are hopelessly selfish and self-absorbed?

Nope. What’s one of the biggest complaints we hear from those we love — especially in the age of smartphones? “You don’t pay enough attention to me.”

And here’s where that meditation-honed attention muscle pays off. You can give them the focus they deserve. When you don’t have to spend most of the day hearing that chatterbox in your head, you can truly listen to the people you care about.

Daniel Siegel explains that those attention skills can powerfully improve relationships with those you love by an increased ability to empathize.

From The Mindful Brain:

Our relationships with others are also improved perhaps because the ability to perceive the nonverbal emotional signals from others may be enhanced and our ability to sense the internal worlds of others may be augmented… In these ways we come to compassionately experience others’ feelings and empathize with them as we understand another person’s point of view.
Spend a little time focusing on your breath every day and you can replace Lefty’s voice with the voice of those you love.

Remember: every time you hit a share button an angel gets its wings. (Or, um, something like that.) Thank you!

 

Email Extras

Findings from around the internet…

+ What’s the best way to take truly restful breaks during the day? Click here. (Written by the very smart Christian Jarrett.)

+ How can your choice of office furniture make you smarter? Click here.

+ Which over-the-counter painkiller works the best? Click here.

+ Miss last week’s post? You definitely need to read “Lefty Part 1.” Here you go: Neuroscience Of Mindfulness: How To Make Your Mind Happy.

+ What’s the best way to motivate people at work? Click here. (Written by that great reader of research Melissa Dahl.)

+ You made it to the end of the email. (I appreciate you waiting to meditate until *after* you finished the email.) Okay, Crackerjack time. Ever hear a song or read something that just “gets you.” It says how you feel better than you could say it yourself? Oh yeah. That feeling. Well, I felt like that yesterday when I read a great comic by the enviably talented (and funny) Matthew Inman. Oh, and it’s about happiness, passion, and doing what you love. Click here.

 

Thanks for reading!
Eric
PS: If a friend forwarded this to you, you can sign up to get the weekly email yourself here.

 

Book Review: Are you looking forward to Christmas… or just wanting to survive it?

Rick Phillips, one of our fellow bloggers, has enjoyed reading Lene Anderson’s book Chronic Christmas, which gives some tips for the less enthusiastic among us on how to make the best of Christmas.

happy-christmas

capture_313x480I was so excited to hear about Chronic Christmas Surviving the Holidays with a Chronic  Illness.  It came to me at exactly the right time of year, and I was in the mood for some fun and practical advice about the holiday season.  When this book arrived in the mail, I was excited to see what Lene might share to help me find that contentment and excitement about the holiday season.  As a person with choric conditions, I sometimes have difficulty getting into the season.  Lene’s words helped me discover some reasons I feel out of step with the rest of the world and gave me practical advice about how to overcome some of my barriers.

Lene shares such wonderful tips for slowing down and basking in the goodness of the holiday season.  Her writing style is easy; her essays are well conceived, and the result is a partial guide to managing the Christmas season with a good touch of fun.  She manages to capture the season in short bursts of narrative that can make even the grumpiest old man find his inner goodness.  Here are a few chapters that especially spoke to me.

December 2, Pace Yourself When Eating.

As a person with diabetes, I often feel left out of the annual celebrations because I see others enjoying food while I enjoy the Television.  In this chapter, Lene reinforces the well know notion that the holidays are not about the food.  Rather they are about who is eating the food.  Her chapter gives me permission to enjoy those who are at the gathering instead of the food at the gathering.   I think it is sometimes difficult for people with diabetes to know this and Lene approached the subject in a way that offers constructive tips.  For instance:

“Moderation is key, Instead of five pieces of Candy stick to one (okay, two).” (Andersen, 2016, p. 7).

“Instead of four glasses of eggnog, have one per occasion and drink sparkling water or tea for the rest of the evening. And so on. You won’t feel deprived. And you won’t stand out as that one person who’s nibbling on a lettuce leaf, making the other guests feel bad for scarfing down everything in sight.” (Andersen, 2016, pp. 7-8)

chronic-christmas-back_314x480December 8, Say Hello

Lene reminds us that we need not remain isolated because we have a chronic condition.  She suggests we try an experiment to break out of our shell.  She suggests that on December 8 we leave the book or earphones at home and practice looking up and out at the world.  She suggests we should look at and marvel in the crowds as they pass by.  She reminds me that people watching is both entertaining and a great way to connect to the world at large.  (Andersen, 2016).  This is great advice for the many times we feel isolated or somewhat alone in the world.  After all, connection is what the holiday season is all about.

For the person who cares about the person with a chronic condition Lene suggests that they offer a drive or a trip to a coffee shop to help people get out in the world.  She suggests:

“Chat with each other, but reach out to others as well. The people at the next table, the clerk, a security guard. Slow down, take the time, exchange a few words. You could very well make someone’s day and you might meet someone really interesting” (Andersen, 2016, p. 35).

These are terrific ideas for helping both ourselves and others.  In fact, opening up during the holidays might make everything brighter.  Lene’s advice gives us the reminder that we need not be isolated while others are engaged in the business of the season.

December 21 – Celebrate Disasters

For me, this was the best advice of the book.  When we celebrate disasters, we have a built in mechanism to make sure things go right.   I love how Lene starts this chapter:

“What do you remember from past Christmases — the times everything went according to plan or the moments when imperfection snuck into the celebrations? We work so hard to make the holidays perfect, but that’s not what makes for enduring family legends. You know the type — the ones that get told and retold, with everyone talking over each other, adding details, and laughing together. Those stories always originate in disasters” (Andersen, 2016, p. 93)

I totally agree with her observation.  The real stories of the season are the ones that revolve around disasters.  So I took this chapter as the best advice I received from Lene’s’ book.    This year, I vow to celebrate the many disasters in my life past, present and future. I will take time to celebrate this year: the time the lock was frozen on the storage barn where I stored the Christmas presents or the time the cat climbed/knocked over the Christmas tree because doing so can prolong the celebration of the season.

So how do I feel about Lene’s book?  I loved it.  You can pick it up on Amazon or Barnes and Noble along with some other retailers.   It is a great gift for those who love people with chronic conditions or those of us who live with chronic conditions.  I am glad I treated myself to this book, and I hope you will as well.   Reading it is way too much fun to miss.

References

 Andersen, L. (2016). Chronic Christmas Surviving the Holidays with a Chronic  Illness. Toronto Two North Books

 

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How does mental distress show physically?

 

8558187594_65216d9621_bAlmost every patient with stress related mental health problems reports at least one somatic symptom and 45 per cent report six symptoms or more, according to a Swedish study of 228 patients suffering from what is termed as exhaustion disorder.

Here is the chart run down of the most common symptoms:

Almost all: Tiredness and low energy

67% Nausea, gas and indigestion

65% Headaches

57% Dizziness

Men and women reported the same number of symptoms.

Chest pain and sexual problems and pain during sex were more reported in men.

Pain in the arms, legs, joints, knees, hips reported more in the over 40s.

The more severe the mental health problem the higher the number of somatic symptoms.

From Human Givens Volume 21 No 1 2014

 

(BMC Psychiatry, 2014, 14, 118)

Although the causes of fibromyalgia are insufficiently understood at present and there is dubiety over whether the condition is due to stress or physical factors I have reproduced a chart which does show many psychosomatic symptoms in its presentation.

 

Symptoms_of_fibromyalgia.png

 

 

 

Health anxiety for diabetics is as bad as for neurological patients

 

girl_suffering_from_anxiety

A quarter of Canadian diabetics, with either type one or two diabetes suffer from a tendency to worry about their health and thus misinterpret bodily sensations as more serious and threatening than they actually are.

Neurological patients have the same degree of anxiety, judged the highest for all patient groups.

Health anxiety was worse in younger patients, females, those recently diagnosed and those who were unmarried.

They had anxiety, a fear of diabetes complications, poorer adherence to dietary and self care activities and a lower physical quality of life.

The researches add, “The cognitive behavioural theory of health anxiety suggests than health anxiety increases when patients feel more vulnerable, perceive the medical condition to be more distressing, feel they are unable to cope with the medical condition, and believe that resources for coping with the medical condition are inadequate.”

From Human Givens Volume 21. No 1 2014

(Janzen Claude JA Hadjistavropoulos, HD and Friesen, L (2014) Exploration of health anxiety among individuals with diabetes: prevalence and implications, Journal of Health Psychology, 19,2 312-22)

A meaningful life will help you live longer and be happier

Having  a sense of purpose in life helps us live longer, and the earlier we discover it, the sooner the protective effects occur. meaning-in-life

Researchers looked at data from over 6,000 participants, focusing on their self reported purpose in life. Over the 14 year follow up period 569 people died and all of those who died had reported less purpose in life and fewer positive relationships with others than did survivors.

Greater purpose in life consistently predicted lower mortality risk right across the lifespan, even when taking into account other markers for psychological and emotional well being.

(Reported in Human Givens Magazine Volume 21, No 1 2014 from a report in  Psychological Science, 2014, doi:10.1177/09567976145311799)

Eric Barker blogs weekly about what will improve your health, happiness and productivity.  Click on this blog post for further information on the same topic:

http://www.bakadesuyo.com/2016/10/meaning-in-life-2/?utm_source=%22Barking+Up+The+Wrong+Tree%22+Weekly+Newsletter&utm_campaign=8491fcb5d5-meaning_10_9_2016&utm_medium=email&utm_term=0_78d4c08a64-8491fcb5d5-57758173

Could Metformin be useful to prevent Alzheimer’s?

 

 

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From Diabetes in Control.
July 16th, 2016
The diabetes drug may have a beneficial effect on neurodegenerative diseases.
Metformin, a biguanide, is an oral diabetes medicine used to improve blood glucose levels in people with type 2 diabetes. There have been various studies on other uses of metformin. It may be beneficial in Alzheimer’s disease, stroke and other degenerative brain cell diseases. An animal study found that metformin helps neurogenesis and enhances hippocampus, a key pathway (aPKC-CBP).

Type 2 diabetes doubles the risk of having dementia; though some studies show metformin helps reduce risk, other studies show antidiabetic medications like insulin are linked to increased risk of having dementia.

Animal studies show that metformin recruits endogenous neural stem cells and also promotes the genesis of new neurons. Metformin, however, needs to have been used for a longer period before a drastic reduction in neurodegenerative disease and its neuroprotective nature is seen.
The purpose of this study is to find a link between antidiabetic medications, especially metformin and other neurodegenerative diseases. Also, to know how long one has to be on these antidiabetics before the neuroprotective nature kicks in.

A cohort study of type 2 diabetes patients who are 55 years and above and being managed on a monotherapy antidiabetic drug of either metformin, sulfonylurea (SU), thiazolidinedione (TZD) or insulin were observed in a period of 5 years.

In the course of 5 years, dementia was identified in 9.9% of the patients. Comparing those taking metformin to those taking sulfonylurea, there was a 20% reduction in dementia in those taking metformin. The hazard ratio 0.79%, a 95% confidence interval of 0.65-0.95.

For TZD, metformin had a 23% reduction in having dementia as compared to TZD with hazard ratio of 0.77, 95% confidence interval of 0.66-0.90.

Whereas those on SU as compared to metformin had a 24% increased risk for dementia with a hazard ratio of 1.24, 95% confidence interval of 1.1-1.4.TZD had an 18% increased risk, hazard ratio of 1.18, 95% confidence interval of 1.1-1.4.

Insulin had the highest risk of 28% with hazard ratio of 1.28, 95% confidence interval of 1.1-1.6.

These findings proved that metformin use has neuroprotective benefits while insulin has an increased risk of one having dementia.
In yet another study, patients 50 years and older from Veterans Affairs, diagnosed with type 2 diabetes, were recruited. Those on insulin were followed from the time they started insulin. The exclusion criteria were neuropathy, vitamin B12 deficiency, cognitive impairment, cerebrovascular disease, renal disease, and those who took insulin for less than two thirds of the study period. The sample size after all exclusions was 6,046 patients with 90% of them being male and a median age of 5.25 years.

334 cases of dementia were diagnosed, 100 of them had Parkinson’s, 71 had Alzheimer’s disease and 19 had cognitive impairment during the follow up period. The incidence of developing neurodegenerative disease was lower (2.08) for those who never used metformin as against those who used it for less than a year, which was (2.47). Metformin usage for 4 years was 0.49, 2 to 4 years was 1.30 and 1.61 for less than 2 years. This proves that the longer one stays on metformin the better the neuroprotective benefits take effect.

This study was significant for dementia (0.567 at 2-4 years and 0.252 for more than 4 years), but for Parkinson’s and Alzheimer’s disease it was 0.038 and 0.229 respectively, which happened from four years and beyond. For future studies, a larger scale prospective cohort study is needed to approve the connection between metformin use and the risk for neurodegenerative disease.

A spatial learning maze test performed on mice showed those given metformin (200mg/kg) were significantly better to be able to learn the location of a submerged platform as compared to those given a sterile saline solution.

Other studies have also proposed that metformin could stimulate neurogenesis from human neural stem cells.
Metformin is known to cross the blood-brain barrier, and has pleiotropic effects. It is known to have other possible preventive roles in cancer and heart disease. From all these various studies, one can conclude that metformin does have a therapeutic potential for mild cognitive impairment and dementia.
Practice Pearls:
Metformin use for more than 2 years has a significant reduction in neurodegenerative disease; it is neuroprotective as well as promoting neurogenesis.
Though the mechanism between metformin and neurodegenerative disease is uncertain, it is known to cross the blood brain barrier and has pleiotropic effects.
Growing evidence suggests that neural stem cells play a role in the repair of injuries or a degenerated brain.

Shi Qian, Lui Shuqian, Foseca Vivian, et al. “The effort of Metformin Exposure on Neurodegenerative disease among Elder Adult Veterans with Diabetes Mellitus”. American Diabetes Association-76th Scientific session 2016. Web June 19 2016.
Wang Jing, et al. “Metformin Activates an Atypical PKC-CBP Pathway to promote Neurogenesis and Enhance Spatial Memory Formation”. Cell Stem Cell. Vol 11(1) July 2012. Web June 19 2016.
Knopman David S et al. “Metformin Cuts Dementia Risk in Type 2 Diabetes”. Alzheimer Association International. July 2013. Web 19 2016.

Depression doubles stroke risk even when treated

Persistent depression is associated with twice the risk of stroke in adults over 50.

Researchers interviewed 16,178 people every two years from 1998 over a 12 year period and assessed depressive symptoms and stroke. They showed that those people who scored significantly for depression on at least two consecutive interviews had double the risk of having a first stroke in the two years after the assessment compared to those with low depressive symptoms. The risk was slightly higher for women and those who had had previous depressive symptoms.

Paola Gilsanz of Harvard University said, ” Our findings suggest that depression may increase stroke risk over the long term. This risk remains elevated even if depressive symptoms have resolved, suggesting a cumulative mechanism linking depression and stroke. Physiological changes may lead to vascular damage over the long term. Depression is also linked to hypertension, ill effects on the autonomic nervous system and inflammatory responses that all cause vascular disease. In addition depressed people are more likely to smoke and by physically inactive.”

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From Research News BMJ 23 May 2015