System changes could make working life better for NHS employees

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Adapted from BMJ 25 October 2025

A Care Under Pressure review by J. Maben et al has examined the causes and solutions to workplace psychological ill health in nurses, midwives and paramedics.

The NHS needs healthy, motivated staff to provide high quality patient care. Nurses, midwives and paramedics make up 56% of clinical staff in the NHS and they have high rates of mental health problems.

High pressure environments with heavy workloads and staff shortages are linked to mental ill health. In 2023 42% of NHS staff reported psychological unwellness due to work related stress. 32% said there was not enough staff to do the job properly and 74% said they suffered from unrealistic time pressures.

Psychological ill health in turn increases staff sickness and resignations. Other staff are under performing because they are at work while under severe psychological stress. Patient care suffers as a result. The estimated cost of this is 12 billion a year to the NHS. The review researchers think that they could save up to 1 billion a year if their recommendations were implemented.

Over 200 research papers were examined for the review. They found that aspects of the job and workplace were more important than the individual profession when it came to the causation of psychological distress.

Those who were most at risk were staff in roles that exposed them to trauma, newly qualified staff and lone workers.

They found that failure to take a long term view of effects on staff, the blame culture, managers who don’t listen to employees, and prioritisation of the needs of the system over the individual, were major causes of psychological distress.

Matters could be improved if the NHS invested in the provision of long term psychological support, reduce bullying and harassment, provide space and places for staff to share experiences and use an evidence based framework to evaluate interventions.

The stigma of having psychological distress in response to work needs to change. The blame culture needs to be tackled. Most staff are simply doing the best they can under very difficult circumstances. Essential needs such as access to hot food, lockers, showers, car parking, rest and break rooms are needed.

Improvements need to be tailored to the local workforce needs. The researchers have produced a summary, guidance and webinar of their work for leaders, nurses, midwives and paramedics.

Amitriptyline improves irritable bowel syndrome in RCT

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Adapted from BMJ 2-9 Nov 2024

I have prescribed Amitriptyline for years for irritable bowel syndrome so I was pleased to see this article that showed a recent RCT gave good results, with the hope that General Practitioners will use it more often.

First line treatments for irritable bowel syndrome include removal of the offending foodstuffs from the diet and the prescription of medication for such symptoms as constipation, diarrhea, and abdominal spasms. Should these not work, low dose anti-depressants including SSRIs and Amitriptyline may be used. This study named ATLANTIS compared Amitriptyline with placebo in patients who had not responded to dietary and simple prescriptions for symptoms.

The study took place in England over 55 practices. Patients described their symptoms as moderate to severe. The average age was 49 and 68% were female. 232 patients were randomised to take the active drug and the other 231 took and identical placebo for six months. The dose was 10mg in the evening increasing to two or three a day depending on symptom control and side effects. Dietary advice from the GPs continued. 338 patients completed the whole six months trial, 75% of the active drug group and 71% of the placebo group. A questionnaire was given to assess symptoms towards the completion of the study.

The Amitriptyline group score for symptoms improved by 99 points compared to 69 points in the placebo group. 61% of the active group reported relief from their symptoms compared to 45% in the placebo group. 58% of the active group thought the treatment was acceptable, compared to 47% in the placebo group. The anxiety, depression, work and social adjustment scores were similar in each group. 20% of the active drug group dropped out of the study compared to 26% in the placebo group.

The active drug users had more of a dry mouth and drowsiness but less insomnia than the active group. There were two “serious” adverse effects in the active group, compared to three in the placebo group. At six months 74% of the active group were still on the medication compared to 68% of the placebo group.

The researchers have said that this is the largest ever trial of Amitriptyline in irritable bowel syndrome. The drug is cheap, reduces symptom severity, is safe and is well tolerated. They hope that this drug will be considered more often for this debilitating condition.

My comment: a low carb diet with removal of wheat from the diet can also improve irritable bowel syndrome and acid reflux.

Hobbies make you happier

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Adapted from BMJ 7 Oct 2023

Engaging with a hobby is associated with better self reported health, happiness and life satisfaction and fewer depressive symptoms.

The proportion of people who report having hobbies varied considerably between countries.

Almost everyone in Denmark said they had a hobby and half of those in Spain had a hobby.

My comment: Having a hobby is dependent on having the free time to have a hobby. There also may be some expense involved. Often hobbies are a way of engaging with other people and sometimes they are solitary pursuits. They are a way of carving out time for yourself, doing something that you enjoy and can even nourish your body, mind and soul. One of the great joys of retirement that I have found is finally having lots of time to enjoy myself. I hope you are able to fit in a bit of what you enjoy into your weekly or monthly routine too.

Cannabis is particularly risky for teenage boys

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Adapted from BMJ 25 Feb 2023

Dr Lade Smith is the first black woman president of the Royal College of Psychiatrists. She is particularly concerned about the rise in psychosis in young people. Much of this is driven by cannabis consumption, particularly from smoking it.

Far from being a benign, relaxing, recreational drug with few downsides, cannabis use in the teens can mar their future. Because cannabis is now quite potent, even use once a week, can drive a five fold increase in psychosis in male users by the age of 25.

She is concerned that recent publicity of the plus sides of cannabis oil use has increased its use overall.

If there is a family history of mental illness, if younger teenage boys use it, if it is smoked, if there are other adverse childhood experiences, then it becomes progressively unsafe. Oestrogen in girls seems to protect them somewhat from the psychotic problems that are more common in boys.

My comment: As a Police Surgeon I was very familiar with the huge increase that I saw over the years in the incidence of psychosis and drug induced psychosis in young people over the years. The brain in these people actually shrinks in size. As they usually need a lot of life long supervision from their families and medical carers, and because they usually become economically inactive for their future lives, it is not good news for the individuals, their families and society in general.

Anxiety is learned from the same sex parent as the child

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Adapted from Medscape News by Megan Brooks July 13 2022

Transmission of anxiety appears to be sex specific. It spreads from mothers to daughters and from fathers to sons, new research shows.

Dr Barbara Pavlova from Nova Scotia says that findings suggest that anxiety is a learned behaviour from parents. Therefore, perhaps it is preventable. Effective treatment of anxiety in young adults, prior to parenthood, could make a difference to children too.

Anxiety disorders are known to run in families. Both genes and environment are thought to be at play.

If a mother for instance has an anxiety disorder, the chance of a daughter developing it, by an average age of 11 years old, is 2.85 times normal, but this is not the case for her son, who would have a normal risk.

Of 398 children studied 27% had been diagnosed with some sort of anxiety disorder including generalised anxiety disorder, social anxiety disorder, separation anxiety disorder or a specific phobia.

The rates increased with the age of the child from 14% in the under 9s to 52% in the over 14s. There was a similar rate of anxiety in both boys and girls. Rates were lower if one parent had the disorder and higher if two parents had the disorder. Dr Pavlova thinks that a child will tend to model themselves on their same sex parent.

Anxiety disorders are the most common psychiatric disorder and emerge earlier than mood disorders.

My comment: I was interested to see this information. My mother had GAD, generalised anxiety disorder, and I have had a specific phobia since I was about 9 (Spiders!). If I was going to get something I suspect that a common specific phobia is a lot less disruptive to life than GAD. The good news is that I’m not a pilot on a jet plane!

A ketogenic drink has been found to improve cognitive performance in those with mild cognitive impairment

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Adapted from A ketogenic drink improves cognition in mild cognitive impairment: Results of a 6 month RCT by Melanie Fortier et al. Alzheimer’s and Dementia. 2021.

Brain energy rescue is being tested to see if it can reduce cognitive decline in patients with mild cognitive impairment. It has previously been discovered that the brain has problems using glucose for fuel even before symptoms develop, but brain ketone use remains constant in both Alzheimers (A) and Mild Cognitive Impairment (MCI). Increasing ketones available to the brain has been shown to improve cognitive symptoms.

A really easy way to increase blood ketone levels is to give a drink containing ketogenic medium chain fatty acids. This has been found to increase brain energy uptake via PET scans. This follow on trial was done to assess whether improvement in cognition after six months occurred.

This study was conducted in Quebec Canada. Very strict entry criteria were applied and the patients were randomised to the ketogenic drink or to a placebo drink. The drinks appeared and tasted identical.

122 participants were enrolled. In total 39 completed the ketogenic arm and 44 the placebo arm. They were well matched regarding age, sex, education, functional ability and cognitive scores, absence of depressive features, blood pressure, blood chemistry and APOE 4 status. ( A genetic variability that greatly increases the chance of developing dementia).

More participants dropped out of the ketogenic group mainly due to gastrointestinal side effects. The drop out rate overall was 32% and 38% in the ketogenic group. None of the side effects were serious.

The results showed that performance on widely used tests of episodic memory, executive function and language improved over 6 months in the ketogenic group compared to the placebo group. Improvement was directly correlated with the plasma level of ketones.

The dose used was 15g of kMCT twice a day.

This seems to be a very reasonable intervention for early cognitive decline particularly since no drugs are approved for MCI and drugs used for Alzheimers do not delay cognitive decline in MCI. It is possible that effects would be enhanced if patients also undertook a ketogenic diet. Further trials are now warranted to see if diagnosis of Alzheimers can be delayed in those suffering from mild cognitive impairment.

Writing down your thoughts can boost your mood

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Adapted from Human Givens No 1 2013 Brinol P et al. Treating thoughts as material objects can increase or decrease their impact on evaluation. Psychological Science 24.1, 41-7. 2013.

Writing down negative thoughts, crumpling them up, and throwing them away, as often advocated by therapists, really does reduce negative thinking. Conversely, writing positive thoughts down, and keeping them safe in a purse or pocket helps you feel better.

Teenage School students in Spain were asked to write down either positive or negative thoughts about their bodies and then Mediterranean diet and they were then evaluated on how much they became influenced by their lists later on.

What they found was that people who threw the list in the trash right away were not influenced, those who kept the list in their desk were somewhat influenced, but that those who kept the list more personally in a pocket or purse were most influenced.

To see if the effect worked with word lists via a computer, the experiment was repeated. The thoughts were put into storage or the trash list. Repeating the experiment but simply asking the students to imagine putting the list in a particular location without physically doing anything was also done.

Professor Richard Petty, a co-author of the paper from Ohio University said, ” The more convinced the person is that negative thoughts are really gone, the better. Just imagining that you throw them away doesn’t seem to work”.

So, to get over a difficult event, write it down, and then bin it and be physical.

If you want to boost your mood, write positive facts or feelings and keep it close and personal.

Nick Norwitz:Ketogenic diets may be used to treat mental illness in the future

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Adapted from Ketogenic diet as a metabolic treatment for mental illness by Nicholas Norwitz et al

Wolters Kluwer Health Inc. http://www.co-endocrinology.com 2020

Ketogenic diets have been used to treat drug resistant epilepsy in children for over one hundred years.

Now they are being used for other neurological conditions such as schizophrenia, depression, bipolar disorder and binge eating disorder.

There is strong evidence that common biological pathologies underlie these conditions such as abnormal glucose metabolism, neurotransmitter imbalances, oxidative stress and inflammation. These factors are all improved with a ketogenic diet.

Controlled clinical trials have shown improvement in: Obesity, Type Two Diabetes, Multiple Sclerosis, Epilepsy, Alzheimer’s disease and Autistic Spectrum Disorder.

Uncontrolled clinical trials have shown improvement in: Parkinson’s disease and Schizophrenia.

Case series and animal models have shown improvement in: Cardiovascular Disease, Binge eating disorder, Major Depressive disorder, Bipolar disorder and ADHD.

It is estimated that people who have mental illness live around 7 to 10 years less than those who do not have a mental illness. Sometimes this is due to suicide, but more often it is due to concurrent diabetes, heart disease, respiratory disease, infectious disease and cancer. All of these conditions are raised in people with mental illness. Sometimes this is due to poor health behaviours such as smoking or other lifestyle issues, and drug side effects can also cause problems. But even in people of a healthy weight and who are not on drugs, if they have mental illness, they are also more likely to have physical illness. Could switching the body and brain away from glucose use towards fat and ketone use improve matters?

Cerebral glucose hypometabolism and insulin resistance are features of Alzheimer’s disease, Parkinson’s disease, Schizophrenia, and Epilepsy. In one recent Cochrane review of epilepsy, as many as 55% of patients had complete remission of their fits on a ketogenic diet.

GABA/glutamate imbalance is a feature of Epilepsy and Schizophrenia. Oxidative stress is a feature of Schizophrenia, Bipolar disorder and Major Depressive Disorder. Oxidative stress and inflammation are mutually reinforcing processes. Major Depressive Disorder, Schizophrenia have these issues.

The Virta Health Group has demonstrated that a ketogenic diet is a well tolerated and effective strategy for treating type two diabetes. It reversed the condition in 54% of patients compared to 5% who received standard care. Alzheimer’s patients also improved on a ketogenic diet and also benefitted from medium chain triglyceride supplementation. (MCTs). Parkinson’s disease, Huntington’s disease and Multiple Sclerosis patients also showed improvement in studies. About 50 to 80% of patients with Alzheimer’s disease have cross over symptoms with schizophrenia, Bipolar disorder and major depressive disorder. These conditions all share common metabolic abnormalities.

It is thought that the ketogenic diet affects the gut microbiome and gut issues are thought to influence Autistic Spectrum Disorder. Two clinical trials reported sometimes complete symptom remission in patients with Childhood Autism when treated with a ketogenic diet.

Some case studies involve psychiatric patients who embarked on ketogenic diets for weight loss and gut problems, only to find a massive improvement in their mental conditions as well. Dr Christopher Palmer reported about an elderly woman with over 50 years of schizophrenia who was able to stop all her antipsychotic medication and has been symptom free for over 12 years. Another middle aged woman who had schizophenia and depression went into complete remission and was able to get her degree and a full time job in the last four years. Both remain unmedicated and on their ketogenic diets.

Results with Binge eating disorder have also been impressive. These patients are usually on 20-30g of carbohydrate a day.

Yoga and dance give pain relief for functional abdominal pain in girls

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Abdominal pain in childhood is associated with increased risk for persistent long term pain and severe mental illness in adulthood. Therefore, it is good to see that a simple intervention of involvement in dance and yoga were considerably more effective in dealing with functional pain than in girls who received standard care.

This was a prospective, multicentre, randomised controlled trial. 121 girls aged between 9 and 13 with functional abdominal pain syndrome or irritable bowel syndrome had standard care or participated in dance and yoga intervention twice a week for 8 months. 55% of the intervention group continued for the whole 8 months of the study.

The dance group were more likely to report a decrease in the maximal abdominal pain at 4 months and 8 months. At 8 months 46% of the dance group reported less pain compared to 17% in the control group.

Hogstrom et al. Dance and yoga reduced functional abdominal pain in young girls. A randomised controlled trial. Eur J Pain. 2021 Sept 16.

Working is good for women’s brains

Adapted from BMJ 21 Nov 2020

Being employed seems to reduce the onset of dementia in women later on in life.

In the USA, 6 thousand women took part in the Health and Retirement study. Rates of memory decline were around 50% faster in those women who did not work for pay in the years after having children. Regardless of marital status and whether they had children, women who worked for pay in early adulthood and midlife showed slower rates of later life memory decline.

My comment: I wonder if the 80 years full time equivalent that I’ve racked up for the NHS will stand me in good stead then?

Once you are old, both men and women’s rates of memory decline from Alzheimer’s greatly accelerates if either experience the death of their spouse.

The Harvard Ageing Brain study did PET scans of participants’ brains at recruitment. They then had annual cognitive assessments. Those who had higher amyloid in the brain to star with deteriorated faster whether they were married or not, but the steepest drop occurred in those whose who were widowed.